Thermodynamics parameters for binding of halogenated benzotriazole inhibitors of human protein kinase CK2α
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چکیده
منابع مشابه
Isomeric Mono-, Di-, and Tri-Bromobenzo-1H-Triazoles as Inhibitors of Human Protein Kinase CK2α
To further clarify the role of the individual bromine atoms of 4,5,6,7-tetrabromotriazole (TBBt), a relatively selective inhibitor of protein kinase CK2, we have examined the inhibition (IC(50)) of human CK2α by the two mono-, the four di-, and the two tri- bromobenzotriazoles relative to that of TBBt. Halogenation of the central vicinal C(5)/C(6) atoms proved to be a key factor in enhancing in...
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15 صفحه اولBinding thermodynamics of substituted diaminopyrimidine renin inhibitors.
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2015
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2015.04.004